External disinfection of calves with BRDC through oxidation therapy
By Dr. J.D. Norris, DVM
My crusade to find an effective solution to Bovine Respiratory Disease began six weeks into a cold wet Texas winter as my wife and I bundled ourselves into heavy coats and rode pens day in and day out, pulling sick calves to treat. The latest pharmaceuticals purchased off the drug truck provided help for some but left the majority unaffected. The day ended with disposing the carcasses of dead calves for the wild animals to dispose of. I began to wonder if we were going about this treatment all wrong. The answers to this question were as unique as the results.
Five years ago my 14-month-old grandson came down with Respiratory Syncytial Virus. I knew about bovine RSV but not the human strain. When my son took him to the pediatrician and RSV was diagnosed, the doctor said to get him to the hospital and under oxygen as soon as possible because the disease is so hard on the lungs. My son mentioned that I had an ozone machine. The doctor agreed ozone was the treatment of choice; if I knew how to administer it, ozone was what he needed.
A year earlier, I had bought an ozone generator for my veterinary clinic, using it to treat respiratory disease in horses as well as small animals at my practice. Having firsthand knowledge of the efficacy and safety of ozone gas, I then contacted Dr. Robert F. Hoffman, a Houston physician, who was conducting research with ozone. He told me how to set the machine; filtering the ozone gas thru olive oil and using a pediatric mask, I let my grandson inhale the ozone for a few seconds each time he went to sleep. Within 48 hours all symptoms had vanished and my grandson was completely healthy.
Following that experience, I continued to use ozone as a main component of Respiratory therapy at my practice with countless recoveries, but I knew I was lacking the knowledge and expertise needed for optimal application.
Finally, I met Peter Conner of Clean Water Ozone Systems Inc., located in Fort Wayne, IN. I told him my story and he said he would be willing to help me. Based on what I learned from my grandson's experience, we have been working on an ozone delivery system for calves which utilize my veterinarian expertise with Peter's vast knowledge of system design and ozone delivery.
Peter Conner first recognized the efficiency of ozone gas (O3) while analyzing its effect on men and equipment in 1964, working as Project Engineer for NASA sounding rockets. His experience with ozone eventually led to the establishment of CleanWater Ozone Systems in 1989, manufacturing ozone systems for agriculture. For over 22 years, Peter has designed and refined hundreds of different Ozone Technology Systems for Municipal and residential drinking water, wastewater treatment facilities, industrial cooling towers, Livestock, and milling plants.
An expert in the field of ozone, Peter has served on the board of Directors for the International Ozone Association since 1995. The IOA was formed in 1973 to serve as the focal point for technology transfer and developments on ozone-related issues. For this purpose, IOA has served as the central, worldwide gathering and disseminating point on ozone information, bringing together scientists, engineers, systems designers, technologists, equipment manufacturers, and end users to share their experiences and research data on ozone and other related oxygen compounds.
After months of painstaking research and development regarding trough size and design, ozone delivery options, ozone concentration and a multitude of related specifics, the Organic disease control system is ready for market.
The Organic Disease Control System is designed with three major factors in mind:
Ozone has been determined to be the most effective disinfectant for water in troughs and other animal watering devices when properly engineered. The effect of ozone below a certain critical concentration value is small or zero. However, above this level all pathogens are eventually destroyed within . This effect is called all-or-none response and the critical level the "threshold value".
- Eliminating viruses, bacteria, and algae and other organic pollutants in watering troughs.
- Eradicating the spread of viral and bacterial disease from one animal to another; and
- Erasing the need for Antibiotics.
Ozone interferes with the metabolism of bacterium-cells, through inhibiting and blocking the operation of the enzymatic control system. Ozone breaks through the cell membrane, and this leads to the destruction of the bacteria instantaneously.
Ozone destroys viruses by diffusing through the protein coat into the nucleic acid core, resulting in damage of the viral RNA. At higher concentrations, ozone destroys the capsid, or exterior protein shell by oxidation so DNA (deoxyribonucleic acid), or RNA (ribonucleic acid) structures of the microorganism are affected.
Because ozone kills bacteria and viruses 3000 times faster than chlorine without leaving any harmful residual, ozone has become the #1 option for ranchers and agribusiness. Ozone remains viable in water for approximately 10-20 minutes; therefore, the Organic Disease Control System operates automatically every 15 minutes and runs for approximately 20 minutes, keeping the watering trough crystal clear and contaminant-free.
Exhaustive testing of the Organic Disease Control System on sick calves has identified a fourth and crucial benefit.
Because its atomic structure makes ozone heavier than air, some ozone gas dissipates from the water and remains above the surface, allowing it to be inhaled as the calf drinks.
The inhaled ozone enters the airways and lungs, killing bacteria and viruses without irritating the respiratory system.
EFFECTIVE BIOSECURITY - EFFECTIVE TREATMENT
An increase in animal density leads to increased microbial load in the environment, and especially the water troughs which act as reservoirs for many bacteria and a transit hub for viruses. According to a study from the Journal of Applied and Environmental Microbiology, troughs can act as long-term reservoirs of organisms with a real potential for infection of cattle, weeks or months later.
Water has been documented to be an excellent Fomite for infection. A Fomite is an inanimate object or substance that acts as vehicle for disease transmission. Therefore, actually maintaining an antiviral/antimicrobial watering trough that the calves enjoy drinking (unlike past attempts to over chlorinate or add chemical disinfectants to the watering troughs in an attempt to accomplish what we have with oxygen) is quite a feat in itself.
We were focused on creating a Low Contamination Environment for the calves at the major portals of entry for infectious agents:
Because the atomic structure of ozone is heavier than air, some ozone gas does not mix with the water but remains on the water's surface allowing it to be inhaled as the calf drinks and permeated upon the conjunctiva of the eye.
Several reports suggest that BVDV is a synergistic agent in mixed infections of the respiratory tract. Viral pathogens most frequently linked with BVDV in respiratory disease include bovine herpesvirus 1 (BHV-1), parainfluenza virus 3 (PI-3V), and bovine respiratory syncytial virus (BRSV). And because these infections are immunosuppressive, much of the economic impact is the result of a weakened immune system, which often leads to secondary respiratory infections and a higher susceptibility to bacterial infections.
That is why we are treating these 4 viruses as well as the major bacterial agents of disease (salmonella, E. coli0157, and M. paratuberculosis , ect.) as an inseparable complex with the key focus on promoting Low environmental contamination which decreases risk of infection and transmission, encouragement of the calves natural immunity to deal with infections through a decrease in viral and bacterial bombardment, and to ensure that only highly susceptible calves, such as PI calves, are affected by the vicious cycle of outbreaks which lead to decreased profit and loss of life.
Ozone Therapy for Bovine Respiratory Disease: A brief overview
The Organic Disease Control System effectively delivers ozone to the calves. We have put over 500 calves through this protocol with extremely positive results. Arriving straight from the sale barn, a load of 125 calves was in-processed and ozone treatment was immediately introduced. 90 percent of calves diagnosed with BRD were diagnosed within the first 30 days after arrival. No antibiotics were given to any of the calves.
The calves were maintained on the Organic Disease Control System for 30 days with 0 head of pulls, and placed back into normal holding pens.
Shortly thereafter, another load of 125 calves was purchased from the same sale barn; however, these calves were not introduced to the Organic Disease Control System but kept with the standard antibiotic protocols. This load of untreated calves required 30 head of pulls and 3 deaths occurred within the first 30 days.
These results have been duplicated many times and we continue to see the same positive outcomes with every system purchased and in use as of today.
I am convinced that the Organic Disease Control System is the only solution to BRD complex that effectively treats and prevents respiratory disease without antibiotic tissue residue. My mission now is to educate and inform ranchers and veterinarians across the US about the Organic Disease Control System.